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Molecular cloning, sequence analysis and coding assignment of the major inner capsid protein gene of human group C rotavirus.

作者信息

Cooke S J, Lambden P R, Caul E O, Clarke I N

机构信息

Department of Microbiology, University Medical School, Southampton General Hospital, United Kingdom.

出版信息

Virology. 1991 Oct;184(2):781-5. doi: 10.1016/0042-6822(91)90452-h.

DOI:10.1016/0042-6822(91)90452-h
PMID:1653500
Abstract

The VP6 gene of human group C rotavirus was cloned and sequenced. Hybridization to the human group C and the porcine group C/Cowden dsRNA genomes assigned this coding sequence to segment 5. The complete human VP6 sequence contained an open reading frame of 1185 nucleotides (395 amino acids; deduced Mr 44,669 Da). The protein sequence demonstrated low homology with the group A VP6 sequences (41.7 to 42.7%) and high homology (88.9%) with the porcine group C VP6 sequence. However, the protein sequence alignments revealed a region of 10 amino acids that were significantly different between the human and the porcine group C viruses.

摘要

相似文献

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