Liu Yaling, Jin Yan, Hu Dahai, Xu Mingda, Dong Maolong, Zhang Yongjie, Xiao Hou'an
Department of Burn Surgery, Xijing Hospital, Fourth Military Medical University, Xian Shaanxi 710032, P R China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2006 Feb;20(2):169-71.
To observe the clinical effect of the human tissue engineered active skin (ActivSkin) with full thickness on the donor site of the split thickness skin graft.
Nine patients with 18 wounds of the donor sites, and every patient had 2 wounds. The wounds of each patient were randomly assigned to the therapy group and the control group. Auto-control observation was performed. Nine donor sites of the split thickness skin graft were repaired with ActivSkin in the therapy group. Nine donor sites of the split thickness skin graft were repaired with the vash oil gauze in the control group. The wound pain, the time to complete closure, and the ratio of the complete healing in the ActivSkin therapy group was measured and compared with those in the control group. The donor sites of the split thickness skin graft were assessed at 180 days of the follow-up visit.
The wound pain was obviously reduced after the harvesting of the skin grafts in the therapy group. The time to complete closure on the donor sites of the split thickness skin graft was significantly shorter in the ActivSkin therapy group than in the control group (9.67 +/- 2.92 d vs. 16. 56 +/- 2.96 d, P < 0.05). Both the ratios of the complete healing in the ActivSkin therapy group and the control group were 100% (P > 0.05). The subsequent results showed that neither the blister nor the residual wound occurred with an alleviated scar after the ActivSkin treatment.
ActivSkin can promote wound closure, prevent blister and residual wound, and alleviate scarring on the donor sites of the split thickness skin graft after the ActivSkin treatment.
观察人全厚组织工程活性皮肤（ActivSkin）对中厚皮片供皮区的临床效果。
9例患者共18处供皮区创面，每位患者有2处创面。将每位患者的创面随机分为治疗组和对照组，进行自身对照观察。治疗组用ActivSkin修复9处中厚皮片供皮区，对照组用凡士林油纱修复9处中厚皮片供皮区。测量并比较治疗组和对照组创面疼痛程度、完全愈合时间及完全愈合率。随访180天时评估中厚皮片供皮区情况。
治疗组取皮后创面疼痛明显减轻。治疗组中厚皮片供皮区完全愈合时间明显短于对照组（9.67±2.92天 vs. 16.56±2.96天，P<0.05）。治疗组和对照组完全愈合率均为100%（P>0.05）。后续结果显示，ActivSkin治疗后未出现水疱和残留创面，瘢痕减轻。
ActivSkin可促进中厚皮片供皮区创面愈合，预防水疱和残留创面，减轻瘢痕。
