Corbin William R, Fromme Kim, Bergeson Susan E
Department of Psychology, University of Texas at Austin, USA.
J Stud Alcohol. 2006 Jan;67(1):5-13. doi: 10.15288/jsa.2006.67.5.
Individual differences in subjective responses to alcohol are believed to have a genetic basis and have been associated with increased risk of alcohol-related problems. There are, however, conflicting results from past studies, perhaps owing to differences in subjective alcohol effects by limb of the blood alcohol curve and the passage of time. The current pilot study evaluated relations among serotonin transporter (SERT) genotype, subjective alcohol responses, and drinking behavior across both the ascending and descending limbs of the blood alcohol curve.
Participants (N=222; 68% male) were administered alcohol (target blood alcohol concentration of .06%) with a subsample (n=86) providing genetic data. Following a social stressor, participants were provided the opportunity to engage in ad libitum alcohol consumption.
SERT transporter was not significantly associated with ad lib drinking or subjective alcohol effects at individual time points, although a trend toward a SERT by blood alcohol concentration limb interaction was observed for ad lib drinking. In addition, SERT genotype predicted acute tolerance to alcohol effects, with participants homozygous for the long SERT allele developing acute tolerance more rapidly than other genotypes.
Although SERT genotype was not reliably associated with ad lib drinking behavior, the results suggest that individuals with the long-long (LL) genotype may develop acute tolerance to alcohol effects more rapidly than heterozygotes or individuals homozygous for the short SERT allele.
人们认为对酒精主观反应的个体差异具有遗传基础，且与酒精相关问题风险增加有关。然而，过去的研究结果相互矛盾，这可能是由于血酒精曲线各阶段以及时间推移导致的主观酒精效应存在差异。当前的初步研究评估了血清素转运体（SERT）基因型、主观酒精反应以及血酒精曲线上升和下降阶段饮酒行为之间的关系。
参与者（N = 222；68%为男性）饮用酒精（目标血酒精浓度为0.06%），其中一个子样本（n = 86）提供基因数据。在经历社会应激源后，让参与者有机会自由饮酒。
SERT转运体在各个时间点与自由饮酒或主观酒精效应均无显著关联，不过在自由饮酒方面观察到SERT与血酒精浓度阶段存在交互作用的趋势。此外，SERT基因型可预测对酒精效应的急性耐受性，携带SERT长等位基因纯合子的参与者比其他基因型的参与者更快产生急性耐受性。
虽然SERT基因型与自由饮酒行为并无可靠关联，但研究结果表明，携带长长（LL）基因型的个体可能比杂合子或携带SERT短等位基因纯合子的个体更快产生对酒精效应的急性耐受性。
