白细胞介素-7与中国HIV-1血清阳性个体疾病进展的关联。

Association of IL-7 with disease progression in Chinese HIV-1 seropositive individuals.

作者信息

Wang Qi, Shang Hong, Wang Ya-nan, Jiang Yong-jun, Liu Jing, Zhang Zi-ning

机构信息

AIDS Research Center, First Affiliated Hospital, China Medical University, Shenyang 110001, China.

出版信息

Chin Med J (Engl). 2006 Feb 20;119(4):288-93.

PMID:16537023

Abstract

BACKGROUND

Elevated levels of interleukin-7 (IL-7) have been correlated with CD4(+) T cell depletion and the emergence of syncytium-inducing (SI) variants in human immunodeficiency virus type-1 (HIV-1) infection, and suggested as an indicator of acquired immunodeficiency syndrome (AIDS) disease progression. Therefore, we investigated the effects of IL-7 on disease progression and virus phenotype in Chinese HIV/AIDS patients.

METHODS

In a cross-sectional study of 71 untreated HIV-1 seropositive individuals and 12 healthy donors, plasma IL-7 levels were determined by an ultra sensitive enzyme-linked immunosorbent assay (ELISA), and its relations to CD4(+) T cells, CD8(+) T cells, plasma viral loads and HIV phenotypes were analyzed.

RESULTS

Significant higher IL-7 levels were found in Chinese HIV/AIDS patients [(3.33 +/- 3.60) pg/ml] than those of health controls [(1.2 +/- 0.81) pg/ml] (P < 0.05), and IL-7 levels were inversely associated with CD4(+) T cell counts (r = -0.497, P < 0.01). Furthermore, IL-7 levels were significant higher in patients with SI variants [(9.12 +/- 4.55) pg/ml] than those with non-syncytium-inducing variants [(1.50 +/- 2.69) pg/ml] (P < 0.01).

CONCLUSIONS

Increased IL-7 levels were found in Chinese HIV/AIDS patients and significantly associated with disease progression, thus increased IL-7 plasma levels may indicate disease progression.

摘要

背景

白细胞介素-7（IL-7）水平升高与人类免疫缺陷病毒1型（HIV-1）感染中CD4(+) T细胞耗竭以及合胞体诱导（SI）变异体的出现相关，并被认为是获得性免疫缺陷综合征（AIDS）疾病进展的一个指标。因此，我们研究了IL-7对中国HIV/AIDS患者疾病进展和病毒表型的影响。

方法

在一项对71名未经治疗的HIV-1血清阳性个体和12名健康供者的横断面研究中，通过超敏酶联免疫吸附测定（ELISA）测定血浆IL-7水平，并分析其与CD4(+) T细胞、CD8(+) T细胞、血浆病毒载量和HIV表型的关系。

结果

中国HIV/AIDS患者的IL-7水平[(3.33 +/- 3.60) pg/ml]显著高于健康对照者[(1.2 +/- 0.81) pg/ml]（P < 0.05），且IL-7水平与CD4(+) T细胞计数呈负相关（r = -0.497，P < 0.01）。此外，SI变异体患者的IL-7水平[(9.12 +/- 4.55) pg/ml]显著高于非合胞体诱导变异体患者[(1.50 +/- 2.69) pg/ml]（P < 0.01）。