溴结构域蛋白4（Brd4）参与1型牛乳头瘤病毒生命周期的多个过程。
Brd4 is involved in multiple processes of the bovine papillomavirus type 1 life cycle.
作者信息
Ilves Ivar, Mäemets Kristina, Silla Toomas, Janikson Kadri, Ustav Mart
机构信息
Institute of Technology, University of Tartu, Tartu 50411, Estonia.
出版信息
J Virol. 2006 Apr;80(7):3660-5. doi: 10.1128/JVI.80.7.3660-3665.2006.
Abstract
Brd4 protein has been proposed to act as a cellular receptor for the bovine papillomavirus type 1 (BPV1) E2 protein in the E2-mediated chromosome attachment and mitotic segregation of viral genomes. Here, we provide data that show the involvement of Brd4 in multiple early functions of the BPV1 life cycle, suggest a Brd4-dependent mechanism for E2-dependent transcription activation, and indicate the role of Brd4 in papillomavirus and polyomavirus replication as well as cell-specific utilization of Brd4-linked features in BPV1 DNA replication. Our data also show the potential therapeutic value of the disruption of the E2-Brd4 interaction for the development of antiviral drugs.
摘要
Brd4蛋白被认为在E2介导的病毒基因组染色体附着和有丝分裂分离过程中作为1型牛乳头瘤病毒（BPV1）E2蛋白的细胞受体。在此，我们提供的数据表明Brd4参与BPV1生命周期的多个早期功能，提出了一种依赖Brd4的E2依赖性转录激活机制，并指出了Brd4在乳头瘤病毒和多瘤病毒复制中的作用，以及Brd4相关特征在BPV1 DNA复制中的细胞特异性利用。我们的数据还显示了破坏E2-Brd4相互作用对抗病毒药物开发的潜在治疗价值。
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