Noda Masaki
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku, Tokyo 101-0062, Japan.
J Pharmacol Sci. 2006 Mar;100(3):211-4. doi: 10.1254/jphs.fmj05004x6. Epub 2006 Mar 14.
Bone formation in adults determines the basic mass of bone and hence it is crucial to understand the mechanisms of its regulation. As remodeling is proceeding, bone resorption is determined by the physical conditions. Especially in women, postmenopausal bone loss is characterized by rapid bone loss due to increase in bone resorption and relative negative balance between such bone resorption and accelerated bone formation. Bone formation is also critical in considering measures to treat patients with very low bone mass. In these subjects, simple suppression of bone resorption would not be enough to maintain bone mass. Thus, bone formation in the adult is of importance in terms of both pathological and therapeutic aspects. This review addresses the possible roles of bone formation modulators in the maintenance of bone mass in the light of understanding the determination of adult bone mass.
成年人的骨形成决定了骨的基本质量，因此了解其调节机制至关重要。随着重塑过程的进行，骨吸收由物理条件决定。特别是在女性中，绝经后骨质流失的特征是由于骨吸收增加以及这种骨吸收与加速的骨形成之间相对负平衡导致的快速骨质流失。在考虑治疗骨量极低患者的措施时，骨形成也很关键。在这些受试者中，单纯抑制骨吸收不足以维持骨量。因此，从病理和治疗方面来看，成年人的骨形成都很重要。鉴于对成年骨量决定因素的理解，本综述探讨了骨形成调节剂在维持骨量方面可能发挥的作用。
