Pajer Z, Kalisnik M
Institute of Histology and Embryology, Medical Faculty, Ljubljana, Yugoslavia.
Oncology. 1991;48(4):317-20. doi: 10.1159/000226950.
In a 46-week-experiment on 72 female mice the influence of peroral 1.2% sodium perchlorate application, total ionizing irradiation with 8 Gy on 5 consecutive days and their interaction on the pituitary-thyroid axis was studied by histological and stereological methods. It was observed that perchlorate alone caused long-term and strong hypothyroidism with hypertrophic and hyperplastic thyroid epithelial cells as well as pituitary thyrotropic cells. When only irradiation was used, no uniform changes in the structure and function of these cells could be detected. The interaction of perchlorate and irradiation showed similar effects as thyrostatics alone, with some exceptions; paradoxically, minor hyperplasia of thyrotropic as well as of parafollicular cells was observed. A high percentage of the follicular cell carcinoma was found after perchlorate application and after its combination with irradiation. No medullary carcinoma was found.
在一项针对72只雌性小鼠的为期46周的实验中，通过组织学和体视学方法研究了经口给予1.2%高氯酸钠、连续5天进行8 Gy的全身电离辐射及其相互作用对垂体 - 甲状腺轴的影响。观察到单独使用高氯酸盐会导致长期且严重的甲状腺功能减退，伴有甲状腺上皮细胞以及垂体促甲状腺细胞的肥大和增生。仅进行辐射时，未检测到这些细胞的结构和功能有一致变化。高氯酸盐与辐射的相互作用显示出与单独使用甲状腺抑制剂相似的效果，但有一些例外；矛盾的是，观察到促甲状腺细胞以及滤泡旁细胞有轻微增生。在给予高氯酸盐及其与辐射联合处理后，发现了高比例的滤泡细胞癌。未发现髓样癌。
