Slovik Youval, Putterman Marc, Nash Michael, Sion-Vardy Netta
Department of Otolaryngology Head and Neck Surgery, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sieva, Israel.
Am J Rhinol. 2006 Jan-Feb;20(1):91-4.
Eosinophilic angiocentric fibrosis (EAF) is an uncommon inflammatory fibrosing lesion involving the upper respiratory mucosa, occurring mainly in young to middle aged women (female/male ratio = 2:1). The etiology is unknown; however, severalfactors might play a role in the development of EAF. Among them are prior nasal trauma (in most of the reported cases nasal surgery had been performed afew years prior to diagnosis) and inflammatory or autoimmune etiology (suggested by the ratio and the fact that in many of the reported cases a history of nonspecific allergy was found).
We report the first case of EAF affecting a male patient who also suffered from chronic inflammatory bowel disease and rheumatic fever.
The patient underwent a diagnostic biopsy of his nasal lesion via an open rhinoplasty approach, with the resulting diagnosis of EAF. Despite the fact that the literature does not show advantages to any specific therapy, the patient elected to remain under observation. During a two-year follow-up period, there is no evidence of progression of disease.
The presence of concomitant rheumatoid arthritis and chronic inflammatory bowel disease in our patient, as well as the fact that nine previously reported cases of EAF had allergic/immune symptoms, raise the possibility that inflammatory or autoimmune factors may have a role in the development of this unusual pathological entity.
嗜酸性粒细胞性血管中心性纤维化（EAF）是一种罕见的累及上呼吸道黏膜的炎症性纤维性病变，主要发生于中青年女性（女性/男性比例=2:1）。病因不明；然而，有几个因素可能在EAF的发生发展中起作用。其中包括既往鼻外伤（在大多数报道病例中，鼻手术在诊断前数年进行）以及炎症或自身免疫病因（从比例以及许多报道病例中发现非特异性过敏史这一事实可推测）。
我们报告首例EAF累及一名同时患有慢性炎症性肠病和风湿热的男性患者。
患者通过开放式鼻整形手术方法对其鼻部病变进行了诊断性活检，结果诊断为EAF。尽管文献未显示任何特定治疗方法具有优势，但患者选择接受观察。在两年的随访期内，没有疾病进展的证据。
我们的患者同时存在类风湿性关节炎和慢性炎症性肠病，以及之前报道的9例EAF病例有过敏/免疫症状这一事实，增加了炎症或自身免疫因素可能在这种不寻常病理实体的发生发展中起作用的可能性。
