Sauer Mary B, Dulac Heidi, Clark Sharon, Moffitt Kim M, Price Jennifer, Dambach Donna, Mosher Howard, Bounous Denise, Keller Lynn
Bristol-Myers Squibb, Department of Veterinary Sciences, Wallingford, CT, USA.
J Am Assoc Lab Anim Sci. 2006 Jan;45(1):30-5.
Rats are used routinely for the discovery of new pharmaceuticals and for toxicology testing to fulfill regulatory requirements. In 1999, a survey showed that 80% of all rodents housed in toxicology studies were housed in wire-bottom cages. However, both the National Research Council and Association for the Assessment and Accreditation of Laboratory Animal Care, International, recommend housing rats in solid-bottom cages with bedding. In this study 2 groups of male Sprague Dawley rats were housed in the same room for 4 wk and provided the same food and water by the same husbandry staff person. The only variable in the study was the type of housing. One group was housed in solid-bottom polycarbonate cages with bedding and the other group in standard wire-bottom caging. Clinical pathology laboratory evaluations of complete blood count, serum chemistries, urinalysis, urine creatinine, urine corticosterone, blood coagulation, and hepatic cytochrome P450 isoenzyme mRNA levels were performed. No clinically relevant differences were found between the 2 groups for any of the laboratory data.
大鼠通常被用于新药研发和毒理学测试，以满足监管要求。1999年的一项调查显示，毒理学研究中饲养的所有啮齿动物中有80%被饲养在铁丝底笼中。然而，美国国家研究委员会和国际实验动物评估和认可协会都建议将大鼠饲养在有垫料的实心底笼中。在本研究中，将两组雄性斯普拉格-道利大鼠饲养在同一房间4周，由同一名饲养人员提供相同的食物和水。该研究中唯一的变量是饲养方式。一组饲养在有垫料的实心底聚碳酸酯笼中，另一组饲养在标准的铁丝底笼中。对全血细胞计数、血清化学、尿液分析、尿肌酐、尿皮质酮、血液凝固和肝细胞色素P450同工酶mRNA水平进行了临床病理实验室评估。两组之间的任何实验室数据均未发现临床相关差异。
