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[镓-67融合单光子发射计算机断层显像/计算机断层扫描图像在淋巴瘤患者中的临床应用价值]

[Clinical utility of fused 67Ga SPECT/CT scan images in patients with lymphoma].

作者信息

Carrera D, Bajén M T, Mora J, Ricart Y, Benítez A, Ferrán N, Guirao S, Fernández-Sevilla A, Martín-Comín J

机构信息

IDIBELL, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona.

出版信息

Rev Esp Med Nucl. 2006 Jan-Feb;25(1):3-9. doi: 10.1157/13083343.

Abstract

AIM

The aim of this work is to show the clinical utility of the fused SPECT 67Ga/CT images in patients with lymphoma.

MATERIAL AND METHOD

44 patients (22 male) with lymphoma have been studied. 22 with Hodgkin's disease and 22 with non Hodgkin lymphoma. 59 studies were performed (33 thorax-cervical [T], 24 abdomen [A] and 2 skull-cervical area [SC]) with an hybrid gammacamera Millenium VG. We acquire consecutively a whole body scan, a SPECT and a CT, for its fusion with the SPECT, of the affects areas. The images were evaluated by two experts blinded, who classify the contribution of the fusion of images respect to the SPECT like: non changes, it improves the location or changes the extension of the injuries and it changes the staging. Final lesion location was confirmed by a high resolution CT performed within one month.

RESULTS

32/59 studies did not change the location or extension of the injuries (20T, 12A), 23/59 studies changed the location or extension of the injuries (12T, 9A and 2 SC) and on 4/59 the change of location induced a change of staging respect to showed by the SPECT.

CONCLUSION

To make fused SPECT 67Ga/CT images in patients with lymphoma allows improving the diagnostic precision in a 46% of the cases, mainly in the abdominal, bone and of the diaphragmatic area studies.

摘要

目的

本研究旨在展示融合的SPECT 67Ga/CT图像在淋巴瘤患者中的临床应用价值。

材料与方法

对44例淋巴瘤患者(22例男性)进行了研究。其中22例为霍奇金病,22例为非霍奇金淋巴瘤。使用Millenium VG混合型γ相机进行了59项检查(33项胸部-颈部[T]、24项腹部[A]和2项颅骨-颈部区域[SC])。我们连续获取全身扫描、SPECT和CT图像,以便将CT与受影响区域的SPECT图像进行融合。由两位不知情的专家对图像进行评估,他们将图像融合相对于SPECT的作用分类为:无变化、改善损伤定位或改变损伤范围以及改变分期。最终病变定位通过在1个月内进行的高分辨率CT得以确认。

结果

59项检查中,32项(20项T、12项A)未改变损伤的位置或范围;23项(12项T、9项A和2项SC)改变了损伤的位置或范围;4项检查中,位置改变导致相对于SPECT显示的分期发生变化。

结论

对淋巴瘤患者进行SPECT 67Ga/CT图像融合可使46%的病例诊断准确性得到提高,主要体现在腹部、骨骼和膈区检查中。

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