[一种培养的甲型肝炎灭活疫苗的免疫原性]

[The immunogenicity of a cultured inactivated hepatitis A vaccine].

作者信息

Kusov Iu Iu, El'bert L B, Kazachkov Iu A, Val'iano N M, Nel'ga I V, Grishina G K, Krutianskaia G L, Lisitsyna E A, Poleshchuk V F, Sobol' A V

出版信息

Vopr Virusol. 1991 May-Jun;36(3):206-9.

PMID:1654007

Abstract

A trial of inactivated hepatitis A viral vaccine of heteroploid cell culture origin is described. The vaccine preparation was tested in guinea pigs and tamarins. The animals were immunized intramuscularly four or three times, respectively. The efficacy was judged by induction of anti-HAV antibody persisting for at least 12 months in guinea pigs, and development of immunity to subsequent virus challenge (monkeys only). The challenge dose of HAV was unable to produce any signs of HAV infection in the vaccinated tamarins, although the booster effect was observed in some animals. The study demonstrated that the tested batches of the vaccine were highly immunogenic.

摘要

本文描述了一项关于异倍体细胞培养来源的甲型肝炎病毒灭活疫苗的试验。该疫苗制剂在豚鼠和绢毛猴身上进行了测试。动物分别通过肌肉注射免疫了四次或三次。通过在豚鼠体内诱导持续至少12个月的抗甲型肝炎病毒抗体以及在后续病毒攻击中产生免疫力（仅针对猴子）来判断疫苗的效力。尽管在一些动物中观察到了加强效果，但甲型肝炎病毒的攻击剂量未能在接种疫苗的绢毛猴身上产生任何甲型肝炎病毒感染的迹象。该研究表明，所测试批次的疫苗具有高度免疫原性。