[甲型肝炎病毒在细胞培养中的增殖]
[The reproduction of the hepatitis A virus in cell cultures].
作者信息
Farashian V R, Bychenko A B, Artemov E K, Kuzaeva I A
出版信息
Vopr Virusol. 1991 May-Jun;36(3):209-12.
A comparative analysis of reproduction of 9 strains of hepatitis A viruses (HSA-15, CF-979, MI, MBB 11/5, H-141, KMW-1, GBM, IH-26, WR-61) from different regions of the world in cell cultures (PLC/PRF/5, HEL-240, FRhK-4, MK) revealed the differences in the capacity of the viruses for reproduction in these cell lines. The factors influencing HAV reproduction in cell cultures such as temperature, medium, and sera were studied. In one-cycle infection, accumulation of vRNA and formation of virus particles were analysed.
对来自世界不同地区的9株甲型肝炎病毒（HSA - 15、CF - 979、MI、MBB 11/5、H - 141、KMW - 1、GBM、IH - 26、WR - 61）在细胞培养物（PLC/PRF/5、HEL - 240、FRhK - 4、MK）中的繁殖情况进行比较分析，结果显示这些病毒在这些细胞系中的繁殖能力存在差异。研究了温度、培养基和血清等影响甲型肝炎病毒在细胞培养物中繁殖的因素。在单周期感染中，分析了病毒RNA（vRNA）的积累和病毒颗粒的形成情况。
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