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内镜治疗在直肠静脉曲张治疗中的价值:硬化注射治疗与套扎治疗的回顾性比较。

The value of the endoscopic therapies in the treatment of rectal varices: a retrospective comparison between injection sclerotherapy and band ligation.

机构信息

Department of Gastroenterology, Sapporo Kosei General Hospital, Sapporo, Japan.

出版信息

Hepatol Res. 2006 Apr;34(4):250-5. doi: 10.1016/j.hepres.2006.01.007. Epub 2006 Mar 15.

Abstract

This study consisted of 15 patients who had undergone endoscopic injection sclerotherapy (EIS) or endoscopic variceal ligation (EVL) for rectal varices. Ten of fifteen patients had histories of anal bleeding, and colonoscopy revealed signs of the risk of variceal rupture in the other five patients. EIS was perfomed in six of the fifteen patients, and the other nine patients underwent EVL. EIS was performed weekly from 2 to 4 times (mean, 3.0), and the total amount of sclerosant ranged from 3.2 to 5.8ml (mean, 4.9ml). After EIS, colonoscopy revealed shrinkage of the rectal varices in all six patients with no complications. EVL was performed weekly from 1 to 3 times (mean, 2.2), and bands were placed on the varices at 2-12 sites (mean, 8.0). After EVL, colonoscopy revealed both ulcers and shrinkage of the varices in the rectum in all nine patients. Eight of the nine experienced no operative complications. However, in the other case, colonoscopy revealed bleeding from ulcers after EVL. The average follow-up period after EIS or EVL was 30 months. The overall non-recurrence rate of rectal varices was 11 of 15 (73.3%); this includes five of the six patients (83.3%) receiving EIS and six of the nine who received EVL (66.7%). The non-recurrence rate was no difference between EIS group and EVL group statistically (P=0.57) by reason of small number of cases. In conclusion, EIS is some superior to EVL with regard to long-term effectiveness, complications on rectal varices.

摘要

本研究纳入了 15 例接受内镜下硬化剂注射治疗(EIS)或内镜下套扎治疗(EVL)的直肠静脉曲张患者。15 例患者中有 10 例有肛门出血史,另外 5 例患者结肠镜检查发现有静脉曲张破裂的风险迹象。15 例患者中有 6 例接受 EIS,9 例接受 EVL。EIS 每周进行 2-4 次(平均 3.0 次),每次使用硬化剂的总量为 3.2-5.8ml(平均 4.9ml)。EIS 治疗后,所有 6 例患者的直肠静脉曲张均有缩小,无并发症发生。EVL 每周进行 1-3 次(平均 2.2 次),在 2-12 个部位放置套扎环(平均 8.0 个)。EVL 治疗后,所有 9 例患者的结肠镜检查均显示直肠静脉曲张伴有溃疡和缩小。9 例患者中 8 例无手术并发症。然而,在另 1 例患者中,EVL 后结肠镜检查显示溃疡出血。EIS 或 EVL 后平均随访 30 个月。15 例患者中 11 例(73.3%)直肠静脉曲张无复发,其中 6 例(83.3%)接受 EIS 治疗,9 例接受 EVL 治疗(66.7%)。由于病例数较少,EIS 组和 EVL 组的直肠静脉曲张无复发率差异无统计学意义(P=0.57)。总之,EIS 在长期疗效和直肠静脉曲张并发症方面优于 EVL。

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