汉方（日本草药）对更昔洛韦耐药的人巨细胞病毒复制的抑制作用。
Inhibition of ganciclovir-resistant human cytomegalovirus replication by Kampo (Japanese herbal medicine).
作者信息
Murayama Tsugiya, Yamaguchi Nobuo, Iwamoto Kozo, Eizuru Yoshito
机构信息
Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.
出版信息
Antivir Chem Chemother. 2006;17(1):11-6. doi: 10.1177/095632020601700102.
We examined the effect of Kampo on the replication of ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) in the human embryonic fibroblast cell line MRC-5. Treatment of HCMV-infected cells with Sho-seiryu-to (SST; Xiao-Qing-Long-Tang in Chinese) resulted in the inhibition of viral replication without affecting the cell growth. SST treatment decreased the synthesis of viral DNA, but had no virucidal effect on cell-free HCMV. However, the inhibitory effect of SST on HCMV replication was ablated by anti-interferon-beta (IFN-beta) antibody suggesting that SST inhibits the replication of GCV-resistant HCMV through the induction of IFN-beta. These results suggest that SST is a novel compund with potential as an anti-HCMV.
我们研究了汉方药对耐更昔洛韦（GCV）的人巨细胞病毒（HCMV）在人胚肺成纤维细胞系MRC-5中复制的影响。用小青龙汤（SST；中文为小青龙汤）处理HCMV感染的细胞可抑制病毒复制，且不影响细胞生长。SST处理可减少病毒DNA的合成，但对游离的HCMV无杀病毒作用。然而，抗β干扰素（IFN-β）抗体消除了SST对HCMV复制的抑制作用，这表明SST通过诱导IFN-β来抑制耐GCV的HCMV的复制。这些结果表明，SST是一种具有抗HCMV潜力的新型化合物。
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