Van Aken Koen, Strekowski Lucjan, Patiny Luc
EcoSynth, Stationstraat 123, B-8400 Oostende, Belgium.
Beilstein J Org Chem. 2006 Mar 3;2(1):3. doi: 10.1186/1860-5397-2-3.
A novel post-synthesis analysis tool is presented which evaluates quality of the organic preparation based on yield, cost, safety, conditions and ease of workup/purification. The proposed approach is based on assigning a range of penalty points to these parameters. This semi-quantitative analysis can easily be modified by other synthetic chemists who may feel that some parameters should be assigned different relative penalty points. It is a powerful tool to compare several preparations of the same product based on safety, economical and ecological features.
本文介绍了一种新型的合成后分析工具,该工具基于产率、成本、安全性、反应条件以及后处理/纯化的难易程度来评估有机制备物的质量。所提出的方法是基于为这些参数分配一系列罚分。这种半定量分析可以很容易地被其他合成化学家修改,他们可能认为某些参数应该被赋予不同的相对罚分。它是一种基于安全性、经济性和生态特征来比较同一产品的几种制备方法的强大工具。