几种I型苯二氮䓬受体配体对不同大鼠脑组织中[³H]氟硝西泮结合的抑制效力。
Potency of several type I-benzodiazepine receptor ligands for inhibition of [3H]flunitrazepam binding in different rat brain tissues.
作者信息
Sieghart W, Schlerka W
机构信息
Department of Biochemical Psychiatry, Psychiatrische Universitätsklinik, Vienna, Austria.
出版信息
Eur J Pharmacol. 1991 May 2;197(1):103-7. doi: 10.1016/0014-2999(91)90371-v.
PMID:1654258
Abstract
The potency of several different non-selective and type I-benzodiazepine receptor-selective ligands as inhibitors of [3H]flunitrazepam binding was measured in different rat brain tissues. In contrast to the non-selective ligands, which had a similar potency in all brain tissues investigated, the potency of the type I-receptor-selective ligands was highest in cerebellar membranes and varied in other brain tissues.
摘要
在不同的大鼠脑组织中测定了几种不同的非选择性和I型苯二氮䓬受体选择性配体作为[³H]氟硝西泮结合抑制剂的效力。与在所有研究的脑组织中效力相似的非选择性配体不同，I型受体选择性配体的效力在小脑膜中最高，在其他脑组织中有所不同。
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