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Nrf2的双刃剑：癌症演变过程中氧化还原稳态的颠覆

The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer.

作者信息

Hayes John D, McMahon Michael

机构信息

Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom.

出版信息

Mol Cell. 2006 Mar 17;21(6):732-4. doi: 10.1016/j.molcel.2006.03.004.

DOI:10.1016/j.molcel.2006.03.004
PMID:16543142
Abstract

Low levels of Nrf2 activity predispose cells to chemical carcinogenesis. Surprisingly, Padmanabhan et al. (2006) provide evidence in a recent issue of Molecular Cell to support the notion that elevated Nrf2 activity may also play a role in the evolution of cancer.

摘要

低水平的Nrf2活性使细胞易发生化学致癌作用。令人惊讶的是，帕德马纳班等人（2006年）在最近一期的《分子细胞》杂志上提供了证据，支持Nrf2活性升高可能也在癌症演变中起作用这一观点。

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