Ferraz Dênis Paiva, Almeida Marco Aurélio S, Mello Bernardo Freire de
Serviço de Endocrinologia, Santa Casa de Misericórdia de Juiz de Fora, MG.
Arq Bras Endocrinol Metabol. 2005 Jun;49(3):460-7. doi: 10.1590/s0004-27302005000300020. Epub 2006 Mar 16.
This paper presents a clinical case of persistent hyperinsulinemic hypoglycemia of infancy (PHHI) and a literature review on this subject. We report on a newborn who presented with hypoglycemic episodes in her first 24 hs of life and was treated successfully with octreotide until the moment. PHHI is the most common cause of persistent hyperinsulinism in infancy and can be hazardous for the development of the central nervous system. There are few current options for clinical treatment, with variable efficacy, and octreotide seems to be the best option before surgical treatment, the only way to control the disease. Preoperative evaluation allows one to adequately distinguish between focal or diffuse processes and suggests the extension of pancreatic resection, improving surgical results and reducing the incidence of postoperative sequelae. Partial pancreatectomy is the procedure of choice in focal disease.
本文介绍了一例婴儿持续性高胰岛素血症性低血糖症（PHHI）的临床病例，并对该主题进行了文献综述。我们报告了一名新生儿，其在出生后的头24小时内出现低血糖发作，截至目前一直用奥曲肽成功治疗。PHHI是婴儿持续性高胰岛素血症最常见的原因，对中枢神经系统发育可能有害。目前临床治疗选择较少，疗效不一，奥曲肽似乎是手术治疗前的最佳选择，而手术治疗是控制该病的唯一方法。术前评估有助于充分区分局灶性或弥漫性病变，并提示胰腺切除的范围，从而改善手术效果并降低术后后遗症的发生率。局部胰腺切除术是局灶性疾病的首选手术方式。
