[不同水平维生素C对紫外线辐射诱导的DNA损伤的影响]
[Effects of different levels of vitamin C on UV radiation-induced DNA damage].
作者信息
Zhou Dian-Feng, Ke Wei-Zhong, Chen Nian-Feng, Ji Kang
机构信息
Jiangsu Provincial Key Lab for Photoelectric Technology, Analysis and Test Center, Nanjing Normal University, Nanjing 210097, China.
出版信息
Guang Pu Xue Yu Guang Pu Fen Xi. 2005 Dec;25(12):2012-5.
The Raman spectra of DNA in different levels of vitamin C with 10 min ultraviolet radiation and 30 min ultraviolet radiation were reported. The intensity of ultraviolet radiation was 18.68 W x m(-2). The experimental results proved that vitamin C can reduce DNA damage solely, but the effects are related to the concentration of vitamin C. When the concentration of vitamin C was lower than 0.35 mmol x L(-1), DNA was protected better with the rising of vitamin C concentration during ultraviolet radiation. DNA was protected best when vitamin C was 0.35 mmol x L(-1). When vitamin C concentration was higher than 0.35 mmol x L(-1), vitamin C accelerated DNA damage with 10 min ultraviolet radiation. But DNA was also protected with 30 min ultraviolet radiation as vitamin C was 0.35-0.65 mmol x L(-1). However, DNA was only protected slightly at high concentration of vitamin C.
报道了在不同维生素C水平下，经10分钟紫外线照射和30分钟紫外线照射的DNA的拉曼光谱。紫外线强度为18.68 W·m⁻²。实验结果证明，维生素C能单独减少DNA损伤，但其效果与维生素C的浓度有关。当维生素C浓度低于0.35 mmol·L⁻¹时，在紫外线照射期间，随着维生素C浓度的升高，DNA得到更好的保护。当维生素C为0.35 mmol·L⁻¹时，DNA得到最佳保护。当维生素C浓度高于0.35 mmol·L⁻¹时，经10分钟紫外线照射，维生素C会加速DNA损伤。但当维生素C为0.35 - 0.65 mmol·L⁻¹时，经30分钟紫外线照射，DNA仍受到保护。然而，在高浓度维生素C时，DNA仅受到轻微保护。
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