Hatta S, Amemiya N, Ohshika H
Department of Pharmacology, Sapporo Medical College, Japan.
Jpn J Pharmacol. 1991 Jul;56(3):385-9. doi: 10.1254/jjp.56.385.
In rat liver at 48 hours after galactosamine (GalN) treatment, isoproterenol-induced accumulation of cyclic AMP and activation of adenylate cyclase (AC) were significantly enhanced. AC activity stimulated with GppNHp or NaF was also augmented in membranes from GalN-treated rats. However, the MnCl2-stimulated or forskolin-stimulated activity in GalN-treated rats did not differ from the control. These data suggest that the beta-adrenergic responsiveness of AC in rat liver is potentiated, possibly due to the enhanced function of the Gs protein, during the process of regeneration after GalN treatment.
在给予半乳糖胺（GalN）处理48小时后的大鼠肝脏中，异丙肾上腺素诱导的环磷酸腺苷（cAMP）积累和腺苷酸环化酶（AC）激活显著增强。用GppNHp或氟化钠（NaF）刺激的AC活性在GalN处理大鼠的膜中也有所增强。然而，GalN处理大鼠中氯化锰（MnCl2）刺激或福斯高林刺激的活性与对照组无差异。这些数据表明，在GalN处理后的再生过程中，大鼠肝脏中AC的β-肾上腺素能反应性增强，这可能是由于Gs蛋白功能增强所致。
