Belfield G P, Delaney S J
Department of Molecular Biology, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK.
Biochem Soc Trans. 2006 Apr;34(Pt 2):313-6. doi: 10.1042/BST20060313.
The discipline of molecular biology has become increasingly important in recent times for the process of drug discovery. We describe the impact of molecular biology across the whole process of drug discovery and development, including (i) the identification and validation of new drug targets, (ii) the development of molecular screens to find new candidate drugs, and (iii) the generation of safety data and competences leading to enhanced clinical efficacy. We also speculate on emerging developments in drug discovery where it seems likely that molecular biology will play an even more vital role in the generation of future therapies.
近年来，分子生物学学科在药物发现过程中变得越来越重要。我们描述了分子生物学在药物发现与开发全过程中的影响，包括：（i）新药物靶点的识别与验证；（ii）用于寻找新候选药物的分子筛选方法的开发；以及（iii）生成安全数据和相关能力以提高临床疗效。我们还推测了药物发现中的新兴发展趋势，在这些趋势中，分子生物学似乎很可能在未来疗法的产生中发挥更为关键的作用。
