[镇静期间基于近似熵和脑电双频指数的意识丧失预测概率比较]

[Comparison of unconsciousness prediction probability with approximate entropy and bispectral index during sedation].

作者信息

Ouyang Ming-wen, Zhang Hong

机构信息

Department of Anesthesiology, General Hospital of PLA, Beijing 100853, China.

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2006 Mar;26(3):287-9.

PMID:16546728

Abstract

OBJECTIVE

To compare the unconsciousness prediction probability (Pk) estimated by approximate entropy (ApEn) and bispectral index (BIS) during the sedation produced by target-controlled infusion (TCI) of propofol.

METHODS

Twenty patients (ASA class I-II) scheduled for elective lower limb operations under epidural anesthesia were studied. TCI of propofol was initiated at target plasma concentration of 0.5 microg/ml, and increased by 0.3 to 0.5 microg/ml until loss of consciousness, and then decreased until consciousness recovery. Each target plasma concentration of propofol lasted for 12 min. ApEn and BIS were recorded simultaneously during the periods of consciousness and unconsciousness every 3 min. The Pk of unconsciousness with ApEn and BIS were calculated and compared.

RESULTS

ApEn was 0.84+/-0.05 in the state of consciousness and 0.71+/-0.06 upon loss of consciousness, and BIS in the corresponding stages were 80.2+/-6.2 and 67.3+/-7.9, respectively. The Pk of unconsciousness between ApEn (Pk=0.97+/-0.06) and BIS (Pk=0.91+/-0.11) did not significantly differ (P>0.05).

CONCLUSION

ApEn as well as BIS is acceptable for predicting consciousness and unconsciousness produced by TCI propofol.

摘要

目的

比较靶控输注丙泊酚镇静期间，近似熵（ApEn）和脑电双频指数（BIS）评估的意识消失预测概率（Pk）。

方法

研究20例计划在硬膜外麻醉下行择期下肢手术的患者（ASA分级I-II级）。丙泊酚靶控输注起始靶血浆浓度为0.5μg/ml，每3min增加0.3~0.5μg/ml直至意识消失，然后降低浓度直至意识恢复。丙泊酚每个靶血浆浓度持续12min。意识期和无意识期每3min同步记录ApEn和BIS。计算并比较ApEn和BIS评估意识消失时的Pk。