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[脑啡肽对出血性大鼠肾脏能量代谢的负面影响]

[The negative effect of enkephalins on kidney energetics in rats with hemorrhages].

作者信息

Slepushkin V D, Grässler Y, Scheuch D W

出版信息

Vopr Med Khim. 1991 Mar-Apr;37(2):51-3.

PMID:1654673
Abstract

Content of adenine nucleotides, lactic and pyruvic acids, glucose and fructose-6-phosphate was studied in kidney of rats with hemorrhage constituting 3% of body mass after intravenous administration at a dose of 100 mg/kg of agonists of mu-opiate receptors DAGO and delta-opiate receptors DADL and dalargin. Stimulation of both these types of receptors amplifies the kidney ischemia developed after hemorrhage, which was expressed as increased decomposition of ATP, decrease in energetic charge of the adenine nucleotide system (DAGO) and increase in content of AMP (DADL, dalargin).

摘要

在静脉注射剂量为100mg/kg的μ-阿片受体激动剂DAGO和δ-阿片受体激动剂DADL及dalargin后,对失血量占体重3%的大鼠肾脏中的腺嘌呤核苷酸、乳酸和丙酮酸、葡萄糖及6-磷酸果糖的含量进行了研究。对这两种类型受体的刺激均会加剧出血后发生的肾脏缺血,这表现为ATP分解增加、腺嘌呤核苷酸系统的能荷降低(DAGO)以及AMP含量增加(DADL、dalargin)。

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