Bozadzhieva E, Savov G, Milanov S, Ovcharuva W, Platonova E
Probl Endokrinol (Mosk). 1975 Mar-Apr;21(2):22-7.
A study was made of 38 persons, including 25--with acromegaly, 5--with chromophobic adenomas of the hypophysis, 3--with diencephalic tumours and 5 healthy individuals. STH, TTH and ACTH were determined in the blood plasma with the aid of radioimmunological methods under basic conditions and L-DOPA loading (10 mg per 1 kg of weight) with insulin (0.10 U/kg). There was an increase in the plasma content of STH, TTH and ACTH with a maximum 60 min after the administration of L-DOPA. In the patients with acromegaly STH increased considerably, and in cases with chromophobic adenomas and diencephalic tumours--less. ACTH level was also elevated. STH and ACTH level rose after insulin hypoglycemia. Possible mechanisms of a stimulating action of L-DOPA and insulin are discussed.
对38人进行了研究，其中包括25例肢端肥大症患者、5例垂体嫌色性腺瘤患者、3例间脑肿瘤患者和5名健康个体。在基础条件下以及左旋多巴负荷（每千克体重10毫克）加胰岛素（0.10单位/千克）的情况下，采用放射免疫方法测定血浆中的生长激素（STH）、促甲状腺激素（TTH）和促肾上腺皮质激素（ACTH）。给予左旋多巴后60分钟时，血浆中STH、TTH和ACTH的含量达到最高值。肢端肥大症患者的STH显著增加，而嫌色性腺瘤和间脑肿瘤患者的增加较少。ACTH水平也升高。胰岛素性低血糖后，STH和ACTH水平上升。文中讨论了左旋多巴和胰岛素刺激作用的可能机制。
