Tkacheva G A, Petrova G A
Probl Endokrinol (Mosk). 1975 Mar-Apr;21(2):62-5.
Experiments were conducted on male Wistar rats. A study was made of the intensity of incorporation into the liver, kidneys, the thyroid gland, the adrenal glands and the rate of elimination from the blood plasma of two ACTH preparations iodated by Greenwood's method: International Standard for Corticotropin, Mill Hill, London; Hum ACTH--Hid-28, Richter. It appeared that the preparations of natural swine -125-I-ACTH and of synthetic -131-I-ACTH were identical chromatographically and by saturation with iodine-125 and iodine-131, respectively, but differed by their behaviour in the organism. T1/2 for -125-I-ACTH (swine) was 4.7 min; the hormone was not incorporated into hepatic parenchyma, and only very weakly--into the kidneys, but it was intensively accumulated by the adrenal galnds. Radioactivity peak was recorded in the adrenal cortex 6 minutes after the administration of the labeled hormone. -131-I-ACTH (synthetic) disappeared from the blood with a falf-period of 11.2 min, was incorporated into the liver and particularly into the kidneys, and was not accumulated in the adrenal gland.
对雄性Wistar大鼠进行了实验。研究了用格林伍德方法碘化的两种促肾上腺皮质激素制剂（伦敦米尔希尔的促肾上腺皮质激素国际标准品；里奇特公司的人促肾上腺皮质激素-Hid-28）在肝脏、肾脏、甲状腺、肾上腺中的摄取强度以及从血浆中的消除速率。结果表明，天然猪源-125-I-促肾上腺皮质激素制剂和合成-131-I-促肾上腺皮质激素制剂在色谱上以及分别用碘-125和碘-131饱和时是相同的，但在生物体内的行为有所不同。-125-I-促肾上腺皮质激素（猪源）的半衰期为4.7分钟；该激素不被肝实质摄取，仅极少量地进入肾脏，但被肾上腺大量蓄积。在给予标记激素6分钟后，肾上腺皮质出现放射性峰值。-131-I-促肾上腺皮质激素（合成）从血液中消失的半衰期为11.2分钟，被肝脏尤其是肾脏摄取，且不在肾上腺中蓄积。
