Wang Ming-peng, Tan Yong-qiang, Zhang Guo-zhen, Zhang Jian-guo, Wu Hao, Yang Jian-ying
Department of Radiology, Shanghai Huadong Hospital, Shanghai 200040, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Feb;28(1):64-7.
To investigate the morphological features of benign and malignant solitary pulmonary nodules (SPNs) and explore the radiological evidences for the differentiation of SPNs.
With SPN Dicom View software, we analyzed and compared images obtained from 23 patients with malignant SPNs and 22 patients with benign SPNs who received CT scanning with or without contrast medium injection.
The enhancement in malignant SPNs group was significantly higher than in the benign SPNs group (P < 0.0001). The irregular enhancement in malignant SPNs group was significantly higher than in the benign SPNs group (P = 0. 0084). The mean range of enhancement was (45.04 +/- 26.76) HU in malignant SPNs group, which was significantly higher than that in the benign SPNs group [(15.70 +/- 17.84) HU, P = 0.033]. The mean peak enhancement value was (136.09 +/- 41.72) HU in malignant SPNs group, which was significantly higher than in benign SPNs group [ (60.60 +/- 60.27) HU, P = 0.007]. The mean enhancement area was (21.69 +/- 21.01)% in malignant SPNs group and (8.61 +/- 10.83)% in benign SPNs group (P = 0.203).
The enhancement range and peak enhancement value as well as the morphologically irregular enhancement of SPNs may provide useful information in the clinical radiological diagnosis of SPNs.
探讨良性和恶性孤立性肺结节（SPN）的形态学特征，探索SPN鉴别诊断的影像学依据。
使用SPN Dicom View软件，分析并比较23例恶性SPN患者和22例良性SPN患者的图像，这些患者均接受了平扫或增强CT扫描。
恶性SPN组的强化程度显著高于良性SPN组（P < 0.0001）。恶性SPN组不规则强化的比例显著高于良性SPN组（P = 0.0084）。恶性SPN组的平均强化范围为（45.04±26.76）HU，显著高于良性SPN组[（15.70±17.84）HU，P = 0.033]。恶性SPN组的平均强化峰值为（136.09±41.72）HU，显著高于良性SPN组[（60.60±60.27）HU，P = 0.007]。恶性SPN组的平均强化面积为（21.69±21.01）%，良性SPN组为（8.61±10.83）%（P = 0.203）。
SPN的强化范围、强化峰值以及形态不规则强化可为SPN的临床影像学诊断提供有用信息。
