Hamy Antoine, Bennouna Jaafar, Heymann Marie-Françoise, Douillard Jean-Yves, Paineau Jacques
Clinique Chirurgicale 1, Centre Hospitalier Universitaire Nord, Nantes, France.
Int Surg. 2005 Sep-Oct;90(4):189-97.
This study includes 16 patients (9 men, 7 women; mean age 64 years) who underwent a total of 19 repeat hepatectomies for metastasis after colon (n=7) or rectal (n=9) carcinoma. All patients were reoperated for recurrent liver metastasis after the first resection (mean, 21 months; range, 7-40 months), and three had a third hepatectomy 13, 24, or 65 months after the second. Perioperative mortality was 0% and morbidity was 37%. The 3- and 5-year survival rates after the second resection were 56.8% and 28.4%, respectively, with a median survival of 42.3 months. Seven patients died (mean survival, 25.7 months; range, 9-58 months) before the end of the study. Six patients were alive with one or more recurrences, and three (24, 51, and 173 months of follow-up) were alive without known recurrence. Survival rates for repeat resections of colorectal liver metastases in selected patients were comparable with those obtained after resection of a first liver metastasis.
本研究纳入了16例患者（9例男性，7例女性；平均年龄64岁），这些患者因结肠癌（n = 7）或直肠癌（n = 9）转移共接受了19次重复肝切除术。所有患者均在首次切除术后因复发性肝转移接受再次手术（平均21个月；范围7 - 40个月），其中3例在第二次手术后13、24或65个月接受了第三次肝切除术。围手术期死亡率为0%，发病率为37%。第二次切除术后的3年和5年生存率分别为56.8%和28.4%，中位生存期为42.3个月。7例患者在研究结束前死亡（平均生存期25.7个月；范围9 - 58个月）。6例患者存活且有一处或多处复发，3例（随访24、51和173个月）存活且无已知复发。特定患者中结直肠癌肝转移重复切除的生存率与首次肝转移切除后的生存率相当。
