Kim Kye Y, Wood Brian E, Wilson Monica I
Veterans Affairs Medical Center, Salem, Virginia 24153, USA.
Consult Pharm. 2005 Mar;20(3):224-30. doi: 10.4140/tcp.n.2005.224.
To review current information on various risk factors of Alzheimer's disease (AD) for clinicians so that they may educate patients or their families in a clinical setting.
Published medical literature and research articles from MEDLINE.
Reviews and articles from 1985 to 2003 concerning risk factors associated with AD.
Data on risk factors ranging from possible or controversial to well established.
AD is an irreversible, progressive neurodegenerative disorder. AD is currently known to be the most common cause of dementia in the United States. Over the last several decades, different levels of risk factors associated with AD have been identified. With more information available to the public via various resources, there is greater need for clinical practitioners to provide up-to-date information on risk factors in a meaningful way. This article discusses advanced age, family history, gender, low education, apolipoprotein E e4, head injury, cardiovascular conditions, and aluminum.
Since there currently is no cure or preventive measure for AD, it is important to educate patients and their families about risk factors of AD in clinical practice.
为临床医生综述有关阿尔茨海默病（AD）各种危险因素的现有信息，以便他们能在临床环境中对患者或其家属进行教育。
来自医学在线（MEDLINE）的已发表医学文献和研究文章。
1985年至2003年有关与AD相关危险因素的综述和文章。
关于从可能或有争议到已明确确立的危险因素的数据。
AD是一种不可逆的、进行性神经退行性疾病。目前已知AD是美国痴呆最常见的病因。在过去几十年中，已确定了与AD相关的不同程度的危险因素。随着通过各种资源向公众提供的信息增多，临床医生更有必要以有意义的方式提供有关危险因素的最新信息。本文讨论了高龄、家族史、性别、低教育水平、载脂蛋白E e4、头部损伤、心血管疾病和铝。
由于目前尚无AD的治愈方法或预防措施，在临床实践中对患者及其家属进行AD危险因素的教育很重要。
