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假性甲状旁腺功能减退症:三例病例系列及手足搐搦症的异常表现。

Pseudohypoparathyroidism: a series of three cases and an unusual presentation of ocular tetany.

作者信息

Sunder R A, Singh M

机构信息

Department of Anaesthesiology, All India Institute of Medical Sciences, New Delhi, India, 110029.

出版信息

Anaesthesia. 2006 Apr;61(4):394-8. doi: 10.1111/j.1365-2044.2006.04543.x.

Abstract

Pseudohypoparathyroidism is a heterogeneous group of disorders characterised by hypocalcaemia, hyperphosphataemia, increased serum parathormone and insensitivity to the biological activity of parathormone. These patients may present for incidental surgery, procedures related to kidney stones, cataract removals and renal transplants. No particular anaesthetic agent or technique is indicated except that respiratory alkalosis should be avoided as it may further decrease ionised calcium levels and thereby precipitate tetany. In this report, we present the peri-operative management of three patients with this rare condition and describe an unusual presentation of hypocalcaemic extra-ocular muscle spasm.

摘要

假性甲状旁腺功能减退是一组异质性疾病,其特征为低钙血症、高磷血症、血清甲状旁腺激素升高以及对甲状旁腺激素的生物活性不敏感。这些患者可能因意外手术、与肾结石相关的手术、白内障摘除术和肾移植手术前来就医。除应避免呼吸性碱中毒外,没有特定的麻醉药物或技术被推荐,因为呼吸性碱中毒可能会进一步降低离子钙水平,从而诱发手足搐搦。在本报告中,我们介绍了三名患有这种罕见疾病患者的围手术期管理,并描述了一种低钙性眼外肌痉挛的不寻常表现。

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