Pectasides Dimitrios, Pectasides Melina, Economopoulos Theofanis
Second Department of Internal Medicine, Propaedeutic, Oncology Section, Attikon University Hospital, 1 Rimini St, Haidari, Athens, Greece.
Oncologist. 2006 Mar;11(3):252-60. doi: 10.1634/theoncologist.11-3-252.
Brain metastases from epithelial ovarian cancer (EOC) are rare. This report is based on a review of the literature.
This review summarizes the incidence, clinical features, pathophysiology, and diagnostic evaluation of EOC. The section on current treatment includes a thorough evaluation of the literature, highlights controversies over treatment options, and provides insight into novel approaches. Current treatment options include surgical resection, whole-brain radiation therapy (WBRT), stereotactic radiosurgery, and chemotherapy. Corticosteroids and anticonvulsant medications are commonly used for the palliation of mass effects and seizures, respectively. In the reviewed series, a better outcome was seen following surgical resection and WBRT with or without chemotherapy for solitary and resectable brain metastases.
The prognosis for patients with brain metastases from EOC is poor. A better outcome might be obtained using multimodality therapy. Because of the small number of patients included in the reported studies, multicenter clinical trials are needed for further investigation in order to critically evaluate the clear benefit of these treatment options in selected patients.
上皮性卵巢癌（EOC）脑转移罕见。本报告基于文献综述。
本综述总结了EOC的发病率、临床特征、病理生理学及诊断评估。当前治疗部分全面评估了文献，突出了治疗方案的争议点，并深入探讨了新方法。当前治疗选择包括手术切除、全脑放疗（WBRT）、立体定向放射外科和化疗。皮质类固醇和抗惊厥药物通常分别用于缓解占位效应和癫痫发作。在综述系列中，对于孤立且可切除的脑转移瘤，手术切除联合或不联合化疗的WBRT后预后较好。
EOC脑转移患者预后较差。采用多模式治疗可能会有更好的结果。由于报告研究纳入的患者数量较少，需要进行多中心临床试验以进一步研究，从而严格评估这些治疗方案对特定患者的明确益处。
