Qureshi Sajid S, Chaukar Devendra A, Talole Sanjay D, Dcruz Anil K
Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, India.
J Surg Oncol. 2006 Apr 1;93(5):362-7. doi: 10.1002/jso.20500.
A significant paucity of data exists on non-squamous cancers of the maxillary sinus. The purpose of this study was to assess the clinical characteristics and outcomes of these tumors.
Retrospective review of 42 patients with complete available data and a diagnosis of non-squamous cancer of the maxillary sinus treated with curative intent between 1994 and 1999 were performed. Information recorded included demography, clinical characteristics, histopathological findings, treatment methods, and outcome. Survival was also compared with that of squamous cancers of the maxillary sinus.
The majority of patients presented with locally advanced disease (83%). Malignancies were 14 sarcomas, 8 adenoid cystic carcinoma, 8 mucoepidermoid carcinoma, 2 adenocarcinoma, and 10 miscellaneous tumors. Fifteen (35.7%) patients developed recurrent disease and six developed distant metastases. The most common site of recurrence was local (32.5%). The overall mean survival was 71.7 months and 5-year overall and disease-free survival was 51% and 48%, respectively. In contrast, the mean survival in the selected 62 patients with squamous cancers was 40 months and 5-year survival was 29% (P = 0.01). Tumor stage, histological, and treatment type was not associated with significant survival advantage.
Patients with non-squamous cancers of the maxillary sinus present with locally advanced disease. Local tumor progression remains a significant pattern of failure; however, unlike squamous cancers they have a better prognosis.
关于上颌窦非鳞状细胞癌的数据极为匮乏。本研究旨在评估这些肿瘤的临床特征及预后。
对1994年至1999年间42例有完整可用数据且经根治性治疗的上颌窦非鳞状细胞癌患者进行回顾性分析。记录的信息包括人口统计学、临床特征、组织病理学发现、治疗方法及预后。还将生存率与上颌窦鳞状细胞癌患者进行比较。
大多数患者表现为局部晚期疾病（83%）。恶性肿瘤包括14例肉瘤、8例腺样囊性癌、8例黏液表皮样癌、2例腺癌和10例其他肿瘤。15例（35.7%）患者出现复发，6例发生远处转移。最常见的复发部位是局部（32.5%）。总体平均生存期为71.7个月，5年总生存率和无病生存率分别为51%和48%。相比之下，所选62例鳞状细胞癌患者的平均生存期为40个月，5年生存率为29%（P = 0.01）。肿瘤分期、组织学类型及治疗方式与显著的生存优势无关。
上颌窦非鳞状细胞癌患者表现为局部晚期疾病。局部肿瘤进展仍是主要的失败模式；然而，与鳞状细胞癌不同，它们的预后较好。
