Manigrasso Annarita, Candioli Salvatore, Maggiani Francesca, Palazzini Giorgio, Filippini Angelo
Università degli Studi di Roma "La Sapienza", Dipartimento di Scienze Chirurgiche, Cattedra di Chirurgia Generale.
Ann Ital Chir. 2005 Jul-Aug;76(4):357-64; discussion 364-5.
The Authors report on two cases of small bowel stromal tumours and underline more recent findings regard to histogenesis, etiopathogenesis and classification as well examine the problems related to diagnosis, surgical management and prognosis of these pathology.
At present, surgical treatment is the best therapy even in patients with local relapse and/or metastasis. Whereas in unresectable patients a new therapeutic possibility is given to the use of Imatinib mesylate, nevertheless is still to prove its effectiveness in regard to survival or as adyuvant treatment in resectable patients with high risk of relapse.
作者报告了两例小肠间质瘤病例，并强调了有关组织发生、病因发病机制和分类的最新研究结果，同时探讨了这些病变在诊断、手术治疗和预后方面的相关问题。
目前，手术治疗是最佳治疗方法，即使是对于局部复发和/或转移的患者。而对于无法切除的患者，甲磺酸伊马替尼提供了一种新的治疗可能性，但仍需证明其在生存方面的有效性，或作为可切除的高复发风险患者的辅助治疗的有效性。
