一种用于快速无标记检测细胞的光学生物传感器。
An optical biosensor for rapid and label-free detection of cells.
作者信息
Acharya Ghanashyam, Chang Chun-Li, Savran Cagri
机构信息
School of Mechanical Engineering, and Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907, USA.
出版信息
J Am Chem Soc. 2006 Mar 29;128(12):3862-3. doi: 10.1021/ja057490l.
We report a broadly applicable optical method for rapid and label-free detection of as few as 45 cells. In this method, bacterial cells are detected by measuring the amount of laser light transmitted through a small glass well functionalized with antibodies which specifically recognize and capture the cells. The described approach is simple, rapid, economical, and promising for portable and high-throughput detection of a wide variety of pathogenic and infectious cells.
我们报告了一种广泛适用的光学方法，可用于快速、无标记地检测低至45个细胞。在该方法中，通过测量透过一个用特异性识别并捕获细胞的抗体功能化的小玻璃孔的激光量来检测细菌细胞。所描述的方法简单、快速、经济，有望用于对多种致病和感染性细胞进行便携式高通量检测。
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