垂体腺苷酸环化酶激活多肽1型和2型受体mRNA在胆结石或胆囊息肉患者胆囊组织中的表达
Expression of pituitary adenylate cyclase-activating polypeptide 1 and 2 receptor mRNA in gallbladder tissue of patients with gallstone or gallbladder polyps.
作者信息
Zhang Zhen-Hai, Wu Shuo-Dong, Gao Hong, Shi Gang, Jin Jun-Zhe, Kong Jing, Tian Zhong, Su Yang
机构信息
No.2 Department of General Surgery, Second Affiliated Hospital, China Medical University, Shenyang, 110004, Liaoning Province, China.
出版信息
World J Gastroenterol. 2006 Mar 7;12(9):1468-71. doi: 10.3748/wjg.v12.i9.1468.
AIM
To detect the expression of pituitary adenylate cyclase-activating polypeptide receptor 1 (VPCAP1-R)and VPCAP2-R mRNA in gallbladder tissues of patients with gallstone or gallbladder polyps.
METHODS
The expression of VPCAP1-R and VPCAP2-R mRNA in gallbladder tissues was detected in 25 patients with gallstone,8 patients with gallbladder polyps and 7 donors of liver transplantation by reverse transcription polymerase chain reaction (RT-PCR).
RESULTS
The VPCAP2-R mRNA expression level in the control group (1.09+/-0.58) was lower than that in the gallbladder polyp group (1.64+/-0.56) and the gallstone group (1.55+/-0.45) (P<0.05) while the VPCAP1-R mRNA expression level in the control group (1.15+/-0.23) was not apparently different from that in the gallbladder polyp group (1.28+/-0.56) and the gallstone group (1.27+/-0.38).
CONCLUSION
The abnormal expression of VPCAP2-R mRNA in gallbladder tissue may play a role in the formation of gallbladder stone and gallbladder polyps.
目的
检测垂体腺苷酸环化酶激活多肽受体1（VPCAP1-R）和VPCAP2-R mRNA在胆囊结石或胆囊息肉患者胆囊组织中的表达。
方法
采用逆转录聚合酶链反应（RT-PCR）检测25例胆囊结石患者、8例胆囊息肉患者及7例肝移植供体胆囊组织中VPCAP1-R和VPCAP2-R mRNA的表达。
结果
对照组VPCAP2-R mRNA表达水平（1.09±0.58）低于胆囊息肉组（1.64±0.56）和胆囊结石组（1.55±0.45）（P<0.05），而对照组VPCAP1-R mRNA表达水平（1.15±0.23）与胆囊息肉组（1.28±0.56）和胆囊结石组（1.27±0.38）相比无明显差异。
结论
胆囊组织中VPCAP2-R mRNA的异常表达可能在胆囊结石和胆囊息肉的形成中起作用。
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