Blasi Giuseppe, Goldberg Terry E, Weickert Thomas, Das Saumitra, Kohn Philip, Zoltick Brad, Bertolino Alessandro, Callicott Joseph H, Weinberger Daniel R, Mattay Venkata S
CBDB, GCAP, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Bethesda, MD 20982-1379, USA.
Eur J Neurosci. 2006 Mar;23(6):1658-64. doi: 10.1111/j.1460-9568.2006.04680.x.
Response inhibition and interference monitoring and suppression are two important aspects of cognitive control. Previous functional imaging studies have suggested a common network of brain regions underlying these cognitive processes; the dorsolateral prefrontal cortex (DLPFC), the ventrolateral prefrontal cortex (VLPFC), the dorsal cingulate (dACC), and the parietal cortex (PC). The relative contribution of these regions to these cognitive subprocesses, however, has not been determined. Based on previous findings supporting a role for dACC in the monitoring of conflicting information within a stimulus, we hypothesized greater activity in this cortical region during interference monitoring and suppression relative to response inhibition. On the other hand, as response inhibition is characterized by differential cognitive processes such as control implementation, top down modulation of the response, expectancy, and inhibition of behavioural response, we hypothesized increased activity in the other cortical nodes of the cognitive control network relative to interference monitoring and suppression. To this end, we conducted an event-related functional magnetic resonance imaging (fMRI) study in 57 healthy volunteers using a task preferentially involving either interference monitoring and suppression or response inhibition. Accuracy for response inhibition was lower than for interference monitoring and suppression. Imaging data showed activation in DLPFC, dACC, VLPFC, PC for both conditions. Comparisons between the two conditions indicated greater activation bilaterally in DLPFC, VLPFC and PC during response inhibition, and greater activation in the dACC during interference monitoring and suppression. These results extend previous findings by suggesting regional functional specialization within a cortical network supporting cognitive control.
反应抑制以及干扰监测与抑制是认知控制的两个重要方面。先前的功能成像研究表明，这些认知过程背后存在一个共同的脑区网络，即背外侧前额叶皮层（DLPFC）、腹外侧前额叶皮层（VLPFC）、背侧扣带回（dACC）和顶叶皮层（PC）。然而，这些区域对这些认知子过程的相对贡献尚未确定。基于先前支持dACC在监测刺激内冲突信息中发挥作用的研究结果，我们假设相对于反应抑制，在干扰监测与抑制过程中该皮层区域的活动会更强。另一方面，由于反应抑制的特征在于不同的认知过程，如控制执行、反应的自上而下调节、预期以及行为反应的抑制，我们假设相对于干扰监测与抑制，认知控制网络的其他皮层节点的活动会增加。为此，我们对57名健康志愿者进行了一项事件相关功能磁共振成像（fMRI）研究，使用的任务优先涉及干扰监测与抑制或反应抑制。反应抑制的准确性低于干扰监测与抑制。成像数据显示，两种情况下DLPFC、dACC、VLPFC、PC均有激活。两种情况之间的比较表明，在反应抑制过程中，DLPFC、VLPFC和PC双侧激活更强，而在干扰监测与抑制过程中，dACC激活更强。这些结果通过表明支持认知控制的皮层网络内的区域功能特化，扩展了先前的研究发现。
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