Stangl K, Baumann G, Gerzer R, Weil J
I. Medizinische Klinik, TU Munich, University of Munich, Germany.
Eur Heart J. 1991 Aug;12(8):917-23.
In eight patients (63 +/- 7.9 years) with angiographically documented dilated cardiomyopathy, we studied the acute effects of a beta-adrenergic stimulation with dobutamine on the plasma levels of atrial natriuretic peptide (ANP) and cyclic guanosine monophosphate (cGMP). For this purpose, a four-point dose-response curve was prepared for dobutamine starting with an initial dose of 2.5 micrograms kg-1 min-1, which was increased by 2.5 micrograms kg-1 min-1 at a time up to altogether 10 micrograms kg-1 min-1. Each stage lasted 15 min. ANP and cGMP were determined from the mixed venous blood before the start (t0), at 5 micrograms kg-1 min-1 after 30 min (t1), at 10 micrograms kg-1 min-1 after 60 min (t2) and after subsidence of the drug effect after 90 min (t3). ANP dropped from 380 +/- 151 pg ml-1 (normal range up to 55 pg ml-1) by 38% to 235 +/- 90 pg ml-1 after 30 min and by another 17% to 171 +/- 45 pg ml-1 after 60 min. After the effect of dobutamine had subsided, an increase by 41% to 325 +/- 139 was reached. There was a parallel drop of the mean cGMP level from 5.4 +/- 1.4 pmol.ml-1 by 28% to 3.89 +/- 1.4 pmol.ml-1 (30 min) and by another 14% to 3.2 +/- 0.7 pmol.ml-1 (60 min). After 90 min it was 18% below the initial value, being 4.4 +/- 1.3 pmol.ml-1.(ABSTRACT TRUNCATED AT 250 WORDS)
在8例经血管造影证实为扩张型心肌病的患者（年龄63±7.9岁）中，我们研究了用多巴酚丁胺进行β-肾上腺素能刺激对血浆心房利钠肽（ANP）和环磷酸鸟苷（cGMP）水平的急性影响。为此，制备了多巴酚丁胺的四点剂量反应曲线，起始剂量为2.5微克/千克·分钟，每次增加2.5微克/千克·分钟，直至总量达10微克/千克·分钟。每个阶段持续15分钟。在开始前（t0）、30分钟后5微克/千克·分钟时（t1）、60分钟后10微克/千克·分钟时（t2）以及90分钟后药物作用消退后（t3），从混合静脉血中测定ANP和cGMP。ANP从380±151皮克/毫升（正常范围高达55皮克/毫升）在30分钟后下降38%至235±90皮克/毫升，60分钟后再下降17%至171±45皮克/毫升。多巴酚丁胺作用消退后，升高41%至325±139。平均cGMP水平从5.4±1.4皮摩尔/毫升平行下降，30分钟时下降28%至3.89±1.4皮摩尔/毫升，60分钟时再下降14%至3.2±0.7皮摩尔/毫升。90分钟后比初始值低18%，为4.4±1.3皮摩尔/毫升。（摘要截短于250字）
