Kloss S, Schuster A, Schroten H, Lamprecht J, Wahn V
Children's Hospital, Düsseldorf, Federal Republic of Germany.
Eur J Pediatr. 1991 May;150(7):483-5. doi: 10.1007/BF01958428.
An 11-year-old boy with chronic granulomatous disease caused by cytochrome b deficiency developed right upper lung lobe aspergillosis. Intracerebral lesions developed on maximum doses of flucytosine and amphotericin B. Treatment with 16 mg/kg oral itraconazole was followed by a dramatic clinical improvement and almost complete disappearance of the intracerebral lesions. Plasma itraconazole levels were between 40 and 3440 ng/ml depending on concomitant medication. Toxicity was restricted to transient elevation of alkaline phosphatase and gamma glutamyl transferase. We conclude that further trials with itraconazole are justified in high risk patients in whom conventional therapy has failed.
一名11岁因细胞色素b缺乏导致慢性肉芽肿病的男孩发生了右上肺叶曲霉菌病。在使用最大剂量氟胞嘧啶和两性霉素B治疗时出现了脑内病变。采用16mg/kg口服伊曲康唑治疗后，临床症状显著改善，脑内病变几乎完全消失。根据联合用药情况，血浆伊曲康唑水平在40至3440ng/ml之间。毒性仅限于碱性磷酸酶和γ-谷氨酰转移酶的短暂升高。我们得出结论，对于传统治疗失败的高危患者，进一步进行伊曲康唑试验是合理的。
