某些含天冬氨酸和谷氨酸的二肽在小鼠脑室内注射后的兴奋作用。

Excitatory action of some aspartate- and glutamate-containing dipeptides after intracerebroventricular injection in mice.

作者信息

Garyaev A P, Dumpis M A, Poznjakova L N, Zaitzev Y V, Piotrovsky L B

机构信息

Department of Pharmacology, Academy of Medical Sciences U.S.S.R., Leningrad.

出版信息

Eur J Pharmacol. 1991 May 17;197(2-3):157-60. doi: 10.1016/0014-2999(91)90515-r.

DOI:10.1016/0014-2999(91)90515-r

PMID:1655472

Abstract

The effects of some dipeptides, analogues of N-acetyl-alpha-L-aspartyl-L-glutamate, were studied after i.c.v. administration into mice in acute experiments. N-Acetyl-alpha-L-aspartyl-L-glutamate itself did not induce seizures in animals, but prevented glutamate-induced convulsions. All other dipeptides possessed excitatory glutamate-like actions. Some structural requirements for the excitatory effects of the dipeptides are discussed.

摘要

在急性实验中，通过脑室内注射，研究了一些二肽（N-乙酰-α-L-天冬氨酰-L-谷氨酸类似物）对小鼠的影响。N-乙酰-α-L-天冬氨酰-L-谷氨酸本身不会诱发动物癫痫发作，但可预防谷氨酸诱发的惊厥。所有其他二肽都具有类似谷氨酸的兴奋作用。讨论了二肽兴奋作用的一些结构要求。