Durcan M J, Morgan P F
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, DICBR, Bethesda, MD 20892.
Eur J Pharmacol. 1991 May 17;197(2-3):209-11. doi: 10.1016/0014-2999(91)90523-s.
The effect of pretreatment with pertussis toxin on N-methyl-D-aspartate (NMDA)-induced seizures was investigated in mice. In animals treated with pertussis toxin (0.5 micrograms/animal i.c.v) five days prior to testing the convulsant ED50 of NMDA was calculated to be 18 mg/kg whereas it was calculated to be 107 mg/kg in sham-treated animals. These results suggest the pertussis toxin enhances sensitivity to NMDA, possibly via its actions on inhibitory G-proteins.
研究了百日咳毒素预处理对小鼠N-甲基-D-天冬氨酸（NMDA）诱导的癫痫发作的影响。在测试NMDA惊厥ED50前五天用百日咳毒素（0.5微克/动物，脑室内注射）处理的动物中，计算出NMDA的惊厥ED50为18毫克/千克，而在假处理动物中计算出的值为107毫克/千克。这些结果表明百日咳毒素可能通过其对抑制性G蛋白的作用增强对NMDA的敏感性。
