Morita Makio, Tokita Masako
Department of Health and Nutrition, Niigata University of Health and Welfare, 950-3198 Niigata City, Japan.
Lipids. 2006 Jan;41(1):91-5. doi: 10.1007/s11745-006-5075-9.
The theory of initiation in lipid autoxidation, which deals with the supply of radicals to the chain reaction, has not been substantively advanced for several decades. Most researchers have long assumed a mechanism of initiation in which main-product hydroperoxide is centrally responsible for autocatalytic radical generation. However, this paper, in which we investigate autoxidizing methyl linoleate, presents decisive evidence against such an assumption: Autoxidation-accelerating activity under mild conditions was not found in the chromatographically separated main-product hydroperoxide fraction but was found in other fractions; and highly active substances with structures containing a peroxide-linked dimer with two hydroperoxy groups were actually obtained.
脂质自动氧化引发理论主要探讨自由基向链反应的供应，几十年来一直没有取得实质性进展。长期以来，大多数研究人员一直假定一种引发机制，即主要产物氢过氧化物是自动催化自由基生成的核心因素。然而，在本文中，我们对亚油酸甲酯的自动氧化进行了研究，提出了反对这一假设的确凿证据：在温和条件下，色谱分离得到的主要产物氢过氧化物馏分未发现有加速自动氧化的活性，而在其他馏分中却发现了这种活性；并且实际上得到了具有含两个氢过氧基的过氧化物连接二聚体结构的高活性物质。
