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原位肝移植治疗终末期肝病:维也纳大学的经验

Orthotopic liver transplantation in the management of end stage liver disease: the University of Vienna experience.

作者信息

Mirza D F, Goetzinger P, Fuegger R, Wamser P, Steininger R, Muehlbacher F

机构信息

Erste Chirurgische Universitaetsklinik (I Department of Surgery), University of Vienna, Austria.

出版信息

Indian J Gastroenterol. 1991 Jul;10(3):92-5.

PMID:1655646
Abstract

Two hundred and eight orthotopic liver transplantations (OLT) were performed in 191 patients at the I Department of Surgery, University of Vienna from 1982-1990. The most frequent indications were hepatocellular carcinoma, alcoholic cirrhosis, posthepatic cirrhosis, primary biliary cirrhosis, and fulminant hepatic failure. Patients with malignancy constituted 33.8% of cases. The overall results showed a 64% one-year and 58% two-year survival; best results were seen in patients with primary biliary cirrhosis and the poorest long-term results were in malignancy. There were 23 postoperative deaths (11%). Primary non-function was seen in 14 (7%) cases; acute rejection episodes were seen in 62% of patients. The presence of a well organised cadaver organ procurement system in eastern Austria with upto 41 donors per million population per year ensures that the 57% growth rate in OLT achieved in 1990 will be maintained with even better results.

摘要

1982年至1990年期间,维也纳大学第一外科为191例患者实施了208例原位肝移植手术。最常见的适应证为肝细胞癌、酒精性肝硬化、肝后性肝硬化、原发性胆汁性肝硬化和暴发性肝衰竭。恶性肿瘤患者占病例的33.8%。总体结果显示,一年生存率为64%,两年生存率为58%;原发性胆汁性肝硬化患者的效果最佳,恶性肿瘤患者的长期效果最差。术后死亡23例(11%)。14例(7%)出现原发性无功能;62%的患者出现急性排斥反应。奥地利东部有一个组织完善的尸体器官获取系统,每年每百万人口有多达41名捐赠者,这确保了1990年原位肝移植实现的57%的增长率将得以维持,甚至取得更好的结果。

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