Narod S A, Lenoir G M
Unit of Mechanisms of Carcinogenesis, International Agency for Research on Cancer, Lyon, France.
Int J Epidemiol. 1991 Jun;20(2):346-8. doi: 10.1093/ije/20.2.346.
Early observations regarding the age of onset, the family history and the clinical pattern of presentation of Wilms' tumour patients have been used to support the two-hit model of carcinogenesis, and to infer the hereditary nature of the bilateral form of the disease. Recent observations drawn from follow-up studies of offspring of unilaterally affected patients cast serious doubts upon the claim that a bilateral tumour implies the presence of an inherited predisposing mutation.
关于肾母细胞瘤患者的发病年龄、家族史和临床表现的早期观察结果，已被用于支持致癌作用的双打击模型，并推断该疾病双侧形式的遗传性质。从单侧患病患者后代的随访研究中得出的最新观察结果，对双侧肿瘤意味着存在遗传性易感突变这一说法提出了严重质疑。
