从阔叶缬草根部提取的具有增强神经生长因子活性的三元环倍半萜类化合物。

Three-membered ring sesquiterpenoids with NGF-potentiating activity from the roots of Valeriana fauriei.

作者信息

Guo Yuanqiang, Xu Jing, Li Yushan, Yamakuni Tohru, Ohizumi Yasushi

机构信息

Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

出版信息

Planta Med. 2006 Mar;72(4):373-5. doi: 10.1055/s-2005-916210.

DOI:10.1055/s-2005-916210

PMID:16557481

Abstract

Three novel three-membered ring sesquiterpenoids, named kissoone A (1), kissoone B (2), and its acetylated product, kissoone C (3), were isolated from the roots of Valeriana fauriei. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2 and 3 showed enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC 12D cells.

摘要

从朝鲜缬草的根部分离出三种新型的三元环倍半萜类化合物，分别命名为缬草酮A（1）、缬草酮B（2）及其乙酰化产物缬草酮C（3）。通过光谱分析阐明了它们的结构。化合物2和3在PC 12D细胞中对神经生长因子（NGF）介导的神经突生长具有增强活性。