葎草变种黄花败酱中具有全新骨架的两个新倍半萜内酯化合物，瓦莱里醇 A 和 B。

Volvalerelactones A and B, two new sesquiterpenoid lactones with an unprecedented skeleton from Valeriana officinalis var. latifolia.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.

出版信息

Org Lett. 2011 Jun 17;13(12):3036-9. doi: 10.1021/ol200878w. Epub 2011 May 18.

DOI:10.1021/ol200878w

PMID:21591723

Abstract

Volvalerelactones A and B (1 and 2), two new sesquiterpenoid lactones with an unprecedented 3/7/6 tricyclic ring system, were isolated from the roots of Valeriana officinalis var. latifolia. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray diffraction crystallography, and the absolute configuration was assigned by computational methods. The possible biosynthetic pathways of 1 and 2 were also proposed.

摘要

缬草内酯 A 和 B（1 和 2）是两种新型倍半萜内酯，具有前所未有的 3/7/6 三环体系，从宽叶缬草根中分离得到。通过光谱数据和单晶 X 射线衍射结晶学阐明了它们的结构和相对构型，并通过计算方法确定了绝对构型。还提出了 1 和 2 的可能生物合成途径。