人参皂苷Re及其代谢产物人参皂苷Rh1对12-氧-十四烷酰佛波醇-13-乙酸酯和恶唑酮诱导的小鼠皮肤炎模型的影响。
The effects of ginsenoside Re and its metabolite, ginsenoside Rh1, on 12-O-tetradecanoylphorbol 13-acetate- and oxazolone-induced mouse dermatitis models.
作者信息
Shin Yong-Wook, Bae Eun-Ah, Kim Sung-Soo, Lee Young-Chul, Lee Boo-Young, Kim Dong-Hyun
机构信息
College of Pharmacy, Kyung Hee University, Seoul, Korea.
出版信息
Planta Med. 2006 Mar;72(4):376-8. doi: 10.1055/s-2005-916217.
The effects of the main constituent ginsenoside Re in ginseng and its metabolite, ginsenoside Rh1, were investigated in 12-O-tetradecanoylphorbol 13-acetate (TPA)- and oxazolone-induced mouse ear dermatitis models. Ginsenoside Rh1 potently suppressed the TPA- and oxazolone-induced swellings as well as mRNA expression levels of cyclooxygenase-2, IL-1beta and TNF-alpha, although these were only weakly inhibited by ginsenoside Re.
在12-氧-十四烷酰佛波醇-13-乙酸酯（TPA）和恶唑酮诱导的小鼠耳部皮炎模型中，研究了人参主要成分人参皂苷Re及其代谢产物人参皂苷Rh1的作用。人参皂苷Rh1能有效抑制TPA和恶唑酮诱导的肿胀以及环氧合酶-2、白细胞介素-1β和肿瘤坏死因子-α的mRNA表达水平，而人参皂苷Re对这些指标仅有微弱的抑制作用。
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