鹦鹉热衣原体在豚鼠白细胞培养物中的干扰素诱导作用。
Interferon induction by the psittacosis agent in Guinea pig leukocyte cultures.
机构信息
Aerobiology and Evaluation Laboratories, Fort Detrick, Frederick, Maryland 21701.
出版信息
Infect Immun. 1970 Dec;2(6):731-4. doi: 10.1128/iai.2.6.731-734.1970.
High titers of interferon were induced by the psittacosis agent in guinea pig leukocyte cultures. Optimal yields of interferon were produced from freshly prepared guinea pig leukocyte cultures containing 4 x 10(6) cells per ml inoculated with a psittacosis/cell multiplicity of 1.0 and incubated at 35 C for 24 hr. Leukocytes obtained from 2- to 4-month-old guinea pigs produced 20 times more interferon than leukocytes from 3- to 4-week-old animals. The biological activity of interferon and the kinetics of its production from psittacosis-infected guinea pig leukocyte cultures were similar to those reported for virus-induced leukocyte interferons.
鹦鹉热病原体在豚鼠白细胞培养物中诱导产生了高滴度的干扰素。最佳产量的干扰素是从新制备的豚鼠白细胞培养物中产生的，每毫升含有 4×10(6)个细胞，接种鹦鹉热/细胞比为 1.0，并在 35°C 孵育 24 小时。从 2 至 4 个月大的豚鼠中获得的白细胞比从 3 至 4 周大的动物产生的干扰素多 20 倍。从鹦鹉热感染的豚鼠白细胞培养物中产生的干扰素的生物学活性及其产生的动力学与病毒诱导的白细胞干扰素相似。
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