Department of Microbiology, University of Iowa, Iowa City, Iowa 52240.
Infect Immun. 1971 Feb;3(2):287-94. doi: 10.1128/iai.3.2.287-294.1971.
A weakly virulent nonencapsulated variant of Cryptococcus neoformans is described. The chemical structure and antigenicity of the soluble polysaccharides produced by the variant strain and a typical virulent strain were compared. The soluble polysaccharides produced by both strains were composed of the same constituent monosaccharides; however, the virulent strain produced a polysaccharide having a greater uronic acid content and a larger molecular size than that of the variant strain. Soluble polysaccharides from the two strains are not closely related immunologically. Soluble polysaccharide obtained from the virulent strain did not affect persistence of the variant strain in mice.
现描述了一种新型隐球菌的弱毒非荚膜变异株。比较了变异株和典型毒力株所产生的可溶性多糖的化学结构和抗原性。两株菌所产生的可溶性多糖均由相同的单糖组成；然而，毒力株所产生的多糖的酸性多糖含量和分子量均大于变异株。两株菌的可溶性多糖在免疫学上没有密切的关系。从毒力株获得的可溶性多糖不会影响变异株在小鼠体内的持续存在。
