抗淋巴细胞血清对小鼠呼肠孤病毒感染的影响。
Effect of antilymphocyte serum on reovirus infection of mice.
机构信息
Department of Microbiology, Tohoku University School of Dentistry, Sendai 980, Japan.
出版信息
Infect Immun. 1971 Feb;3(2):304-7. doi: 10.1128/iai.3.2.304-307.1971.
Abstract
Reovirus type 3 infection in mice was investigated, with particular reference to the effect of antilymphocyte serum. With virus inoculation, a characteristic acute disease was manifested in the mice younger than 5 days old but not in mice 7 days old or older. However, a single injection of antilymphocyte serum, which was prepared in rabbits immunized with mouse thymocytes, followed by virus inoculation induced the acute disease in mice 7 days old or older. The latter result suggests that this production of the acute disease may be due to a suppression of the cellular immune mechanism sensitive to antilymphocyte serum.
摘要
研究了小鼠的 3 型呼肠孤病毒感染，特别关注了抗淋巴细胞血清的影响。在病毒接种后，5 天龄以下的小鼠表现出特征性的急性疾病，但 7 天龄或更大的小鼠则没有。然而，单次注射用兔抗胸腺细胞免疫制备的抗淋巴细胞血清，随后接种病毒，可诱导 7 天龄或更大的小鼠发生急性疾病。后一结果表明，这种急性疾病的产生可能是由于细胞免疫机制对抗淋巴细胞血清敏感而受到抑制。
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