Bartnicki-Garcia S, Nickerson W J
Institute of Microbiology, Rutgers, The State University, New Brunswick, New Jersey.
J Bacteriol. 1961 Jul;82(1):142-8. doi: 10.1128/jb.82.1.142-148.1961.
Bartnicki-Garcia, S. (Rutgers, the State University, New Brunswick, N. J.), and Walter J. Nickerson. Thiamine and nicotinic acid: Anaerobic growth factors for Mucor rouxii. J. Bacteriol. 82:142-148. 1961.-Mucor rouxii requires preformed thiamine and nicotinic acid for anaerobic growth. Such requirements are not manifested during aerobic incubation. Aerobically, the fungus was shown to be able to synthesize both vitamins. The yeastlike form and the filamentous form of anaerobically grown M. rouxii exhibit the same vitamin requirements. Thiamine can be substituted by its thiazole moiety. Under certain conditions, nicotinic acid was partly substituted by tryptophan, kynurenine, 3-hydroxykynurenine, and 3-hydroxyanthranilic acid.Anaerobically. the fungus (thiamine requiring) was about ten times more susceptible to pyrithiamine antagonism than the same organism grown aerobically (thiamine independent).
巴特尼基 - 加西亚,S.(罗格斯州立大学,新不伦瑞克,新泽西州),以及沃尔特·J.尼克森。硫胺素和烟酸:鲁氏毛霉的厌氧生长因子。《细菌学杂志》82:142 - 148。1961年。——鲁氏毛霉厌氧生长需要预先形成的硫胺素和烟酸。在有氧培养期间不会表现出这种需求。在有氧条件下,该真菌能够合成这两种维生素。厌氧培养的鲁氏毛霉的酵母样形态和丝状形态表现出相同的维生素需求。硫胺素可以被其噻唑部分替代。在某些条件下,烟酸部分被色氨酸、犬尿氨酸、3 - 羟基犬尿氨酸和3 - 羟基邻氨基苯甲酸替代。在厌氧条件下,(需要硫胺素的)该真菌对硫胺素拮抗物的敏感性比在有氧条件下生长(不依赖硫胺素)的同一生物体高约十倍。