Jacks T M, Glantz P J
Department of Veterinary Science, Pennsylvania State University, University Park, Pennsylvania.
J Bacteriol. 1967 Mar;93(3):991-5. doi: 10.1128/jb.93.3.991-995.1967.
A study was undertaken to determine whether virulence in mice could be used to assess the pathogenicity of a variety of Escherichia coli serotypes. Sixty-one E. coli strains isolated from animals, poultry, or humans were serotyped to determine their O, K, and H antigens, and were administered to mice via the intraperitoneal route with and without a mucin adjuvant. The ld(50) dose was then determined for each serotype. The results indicated that the source of the serotype may be associated with virulence for mice. Serotypes isolated from nonenteric, systemic sources showed a greater virulence for mice inoculated intraperitoneally than did the enteric and the nonenteric, nonsystemic (localized) isolates. It was observed that not all serotypes belonging to a specific serogroup were virulent for mice and that the presence or absence of a K antigen had no effect on the virulence of strains of one serotype.
开展了一项研究，以确定小鼠的毒力是否可用于评估多种大肠杆菌血清型的致病性。从动物、家禽或人类中分离出61株大肠杆菌，对其进行血清分型以确定它们的O、K和H抗原，并在有和没有粘蛋白佐剂的情况下通过腹腔途径将其接种给小鼠。然后确定每种血清型的半数致死剂量（ld50）。结果表明，血清型的来源可能与对小鼠的毒力有关。从非肠道、全身性来源分离出的血清型对经腹腔接种的小鼠显示出比对肠道以及非肠道、非全身性（局部）分离株更大的毒力。据观察，并非属于特定血清群的所有血清型对小鼠都有毒力，并且K抗原的存在与否对一种血清型菌株的毒力没有影响。
